https://doi.org/10.22184/2227-572X.2023.13.1.56.59

This article is an overview description of exposomics that is a concept and a modern field of biomedical and chemical-­analytical research related to the study of the integrity of various exposures to a human body over a long time period. The complicated structure and compo­nents of an exposome are considered. The external and internal exposomes and their chemical components, including exogenous compounds, products of their biotransformation and endogenous metabolites, are identified. It is indicated that the development of exposomics in its chemical aspects is based on the use of nontarget chemical analysis techniques, including various variants of chromatography and mass spectrometry. The development of data science is characterized, the consequence of which is the emergence of numerous databases in which the relationship between various chemical compounds and certain diseases is outlined. The goals of exposomal research that are or should be carried out by analytical chemists, are formu­lated.